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Try Metformin for Anti-Aging
Metformin is an FDA-approved drug for type 2 diabetes, but it’s also used off-label for aging research. It may help improve metabolic and cellular processes that tend to decline with age:
- Boosts AMPK activity — an important energy sensor in cells that helps improve insulin sensitivity, reduce inflammation, and support cell repair
- Influences sirtuin pathways — proteins tied to longevity, cellular protection, and stress response
- Suppresses mTOR signaling, which is linked to cell growth and aging when overactivated
These combined effects may support healthier aging, better metabolism, and improved cellular resilience.
How does it work?
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What is Metformin?
Metformin is a prescription medication primarily used to treat type 2 diabetes mellitus, a condition characterized by high blood sugar levels due to insulin resistance or inadequate insulin production. It belongs to the class of drugs known as biguanides. Metformin works by decreasing glucose production in the liver, improving insulin sensitivity in tissues, and reducing the absorption of glucose from the gastrointestinal tract. This leads to lower blood sugar levels and better control of diabetes. Metformin has also been prescribed off-label for its anti-aging effects, reduction of certain types of cancers and to promote weight loss.
How to take Metformin?
Metformin comes as an extended-release tablet and is taken once per day with food. It is recommended to take Metformin around the same time each day. Follow the directions on your prescription label carefully. Take Metformin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
How quickly will I notice results?
Some improvements in energy and metabolic markers may appear within weeks. More notable changes (e.g., reduced inflammation, more endurance) typically occur around 3-6 months, depending on lifestyle.
Can I stop taking it?
You may discontinue at any time under medical advice. Benefits often wane after stopping, so consistency is key for lasting effects.
What if I miss a dose?
Take it as soon as you remember, unless it’s almost time for your next dose. Do not double up.
What to Expect & Timeline:
- Some benefits may begin in weeks to a few months (e.g, energy, metabolic markers)
- More measurable changes typically appear over 3-6 months
- Full long-term effects depend on consistent use and overall health habits (diet, activity, sleep)
- Regular check-ins with your provider can help monitor results and adjust as needed
How to Take Metformin:
- Take one tablet daily, preferably with a meal, to reduce stomach upset
- Use the extended-release form as prescribed
- Try to take it at roughly the same time each day
- Store as instructed; maintain regular use for ongoing benefits
Safety & Possible Side Effects:
Metformin is usually well tolerated. Some side effects may include:
- Gastrointestinal issues (nausea, diarrhea, gas) — often temporary or eased with extended-release formulation
- Possible reduction in vitamin B12 levels; periodic monitoring recommended
- Minor appetite changes, altered taste
- Rare risk of lactic acidosis, especially in individuals with kidney or liver issues or low hydration — speak with your provider.
- Use caution if combining with other medications that impact blood sugar.
